Ramucirumab (IMC-1121B) is a fully human monoclonal antibody (IgG1) for the treatment of solid tumors. It is directed against the vascular endothelial growth factor receptor 2 (VEGFR2). By binding to VEGFR2 it works as a receptor antagonist blocking the binding of vascular endothelial growth factor (VEGF) to VEGFR2.

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A randomised non-comparative phase II trial of cixutumumab (IMC-A12) or ramucirumab (IMC-1121B) plus mitoxantrone and prednisone in men with metastatic docetaxel-pretreated castration-resistant Table 1. Patient Demographics and Clinical Characteristics - "Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2." Comparison of IMC-1121B Stability in PBS and 10 mM Histidine Buffer (pH 6.0) Formulations. DOE screening studies predicted that the IMC-1121B antibody has significantly better stability in a 101 mM histidine buffer (pH 6.0) formulation than in PBS. 2010-07-01 · Ramucirumab (IMC-1121B): Monoclonal antibody inhibition of vascular endothelial growth factor receptor-2. Spratlin J. Curr Oncol Rep, 13(2):97-102, 01 Apr 2011 Cited by: 39 articles | PMID: 21222245.

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endoteltillväxtfaktor (VEGF) -A-antikropp bevacizumab (Avastin®) 34, anti-VEGFR2-antikropp ramucirumab (IMC-1121B) 35 och aflibercept (VEGF-Trap) 36 .

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Ramucirumab is currently being investigated in multiple clinical trials across a variety of tumor types. Ramucirumab (IMC-1121B): a novel attack on angiogenesis. Spratlin JL(1), Mulder KE, Mackey JR. Author information: (1)Department of Medical Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, AB T6G 1Z2, Canada. jennifer.spratlin@albertahealthservices.ca IMC-1121B binds to receptors for a protein called vascular endothelial growth factor (VEGF), which may be found on some types of cancer cells.
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Ramucirumab is a direct VEGFR2 antagonist, that binds with high affinity to the extracellular domain of VEGFR2 and block the binding of natural VEGFR ligands (VEGF-A, VEGF-C and VEGF-D). Buy VEGFR/PDGFR inhibitor Ramucirumab (LY3009806; IMC-1121B) from AbMole BioScience.

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imc-1121b Immunoglobulin G1, anti-(human vascular endothelial growth factor receptor type VEGFR-2 extracellular domain) (human monoclonal IMC-1121B gamma-chain), disulfide with human monoclonal IMC-1121B kappa-chain, dimer

Phase I clinical trials have shown safety across a wide range of ramucirumab doses with impressive, albeit early, evidence of both stable disease and partial responses in a variety of tumor types. Ramucirumab (IMC-1121B; ImClone Systems Corporation, Branchburg, NJ) is a fully human monoclonal antibody developed to specifically inhibit VEGFR-2.

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